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doi: 10.1038/nm730 21 FreemanGJLongAJIwaiYBourqueKChernovaTNishimuraHet al

The pentose phosphate pathway is the only source of NADPH in red blood cells, and the major function of NADPH in this cell type is to maintain the tripeptide glutathione (GSH) in its reduced state, which is needed to detoxify reactive oxygen species (Figure 3)

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Fatty acid synthesis consumes NADPH and generates NADP, serving as an electron sink and contributing to redox balance 318

Morning Sickness results from an overproduction of histamine and a reduced ability to break it down