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Am J Physiol Renal Physiol 307(7):F777-82, 2014

Intriguingly, several reports indicate that HIF1 binds and regulates the expression of multiple Jumonji-domain containing histone demethylases (JMJHDs), which may contribute directly to changes in hypoxic target gene expression 31,34

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But: Taper slowly and withdrawal is much more manageable Not everyone gets withdrawal symptoms Withdrawal isnt dangerous, just uncomfortable The longer-acting ones (like fluoxetine) have easier withdrawal This is a reason to be thoughtful about stopping, not a reason to avoid starting if you need the medication