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In the context of artificial lungs, this would mean constant infusion, since suppressing blood clotting for several days, weeks or months requires a long circulation time

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Given that a 40 g mouse drinks approximately 6 mL per day, we diluted respectively 0.2 mg of dyclonine/Sm5 (0.2 mg in 40 g = 5 mg/kg) and 0.02 mg of leucovorin/Sm11 (0.02 mg in 40 g = 0.5 mg/kg) in 6 mL, scaling these drug concentrations to a total volume of 200 mL per bottle