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Trimethylamine N-oxide (TMAO), an important gut microbe-dependent metabolite, is generated from dietary choline, betaine, and L-carnitine

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10.1016/j.phymed.2021.153662 97 LiD.KeY.ZhanR.LiuC.ZhaoM.ZengA.et al (2018)

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Therefore, it can be stated that NOD2 mutations are predominantly found in European populations, whereas Asian populations such as the Japanese and Chinese generally do not exhibit a high prevalence of these genetic variations

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