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opposita , contains dioscin, which down-regulates TGF-1 and phosphorylated Smad3 (p-Smad3), and up-regulates Smad7 in a fructose-induced kidney injury model, exerting anti-fibrotic effects (99)

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Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkins protective function