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A trial published in the Journal of Hepatology in 1999 found SAMe to be effective in reducing mortality and the need for liver transplantation in patients who did not already suffer from advanced alcoholic cirrhosis

Figure 5B shows total reduced-thiol levels in untreated and tamoxifen treated cells, whereby tamoxifen treatment caused a drastic decline in total reduced-thiol levels in CHO R C5 cells relative to AuxB1 cells at 5 M