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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

444 For example, OT administration increases the connectivity of brain regions critical for processing socioemotional information, such as the NAc, amygdala and PFC

doi: 10.1152/ajpheart.00699.2006

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Following subcutaneous injection in human studies: Bioavailability approaches 100% with subcutaneous administration Time to maximum plasma concentration (Tmax) occurs at approximately 1.0 hour (range 0.5-1.0 hours) Maximum plasma concentration (Cmax) averages 72.8 ng/mL Area under the curve (AUC) measures 276 hrng/mL The peptide exhibits relatively low plasma protein binding at 21% , allowing substantial free drug availability for central nervous system penetration