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Description

Barker-Haliski, M

Blood was drawn from the tail vein of each mouse into tubes containing 1 mM EDTA as an anticoagulant

Acetaminophen (paracetamol) depletes glutathione during its own metabolism via the CYP450 pathway, and alcohol consumption already suppresses glutathione by 4050%

Note that a standard drink varies by different types of alcohol

The change induces difficulty in repairing ruptures of double-stranded DNA, increases ROS production, mitochondrial dysfunction, with concomitant oxidative stress and consequent cell apoptosis [10, 11]