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The catalase enzyme (CAT) subsequently breaks down H 2 O 2 into H 2 O and O 2 , or it can be transformed by thiol peroxidases, such as glutathione peroxidase, which promote the reduction of H 2 O 2 and/or organic hydroperoxides into water and the corresponding alcohols

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Thus, CHAC1 serves a dual role: it preserves mitochondrial function by ensuring a cysteine supply under nutrient stress, but it also facilitates ferroptosis by maintaining ETC activity, highlighting its potential as a therapeutic target in cancer treatment (Ward et al., 2024)