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Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming

The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events

doi: 10.1001/jamaneurol.2017.3098 8 BovJ.Martnez-VicenteM.DehayB.PerierC.RecasensA.BombrunA.et al

However, only two pH values were evaluated, so no specific conclusion could be drawn from those studies [25]