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Thus, along with its properties as an antioxidant, NAC will also increase GSH, possibly preserving or enhancing GPX1 function [43]

In this cells, the apoptotic pathway relied upon the same Trx1/p38MAPK/p53 signaling axis and cell survival to diamide relied upon redox activation of NE2FL2, in a way independent of Keap1 oxidation, but responsive to ERK1/2 activation (Filomeni et al., 2012)

Nature 389, 816824

Patent US8709515

The one-carbon metabolic pathway, which comprises three critical reactions (i.e., folate and methionine cycles), underlies this effect in conjunction with the trans-sulfuration pathway