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can directly interact with epidermal cells by activating inflammatory pathways and their effectors such as mitogen-activated protein kinase (MAPK), NFB, and nuclear factor of activated T cell (NFAT) [19]

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Furthermore, sex hormones may influence the enzymatic synthesis of long-chain polyunsaturated FAs, which may lead to sex-specific differences in long-chain polyunsaturated FA status (Decsi and Kennedy, 2011)