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Notably, compared with A2ARi or Lip-1 treatment alone, combination of both increased the OCR in activated CD8 + T cells cultured under hypoxia conditions (Figure 5H)

May lower requirements for: Vitamin A Increase levels of the vitamin A transport protein and vitamin A in the blood

If you're skilled in this area, you can use webtools to look at single-cell expression and chromatin states, which is pretty neat

Hunter CA, Yu D, Gee M, Ngo CV, Sevignani C, Goldschmidt M, et al

The combination treatment enhanced mitochondrial oxidative phosphorylation, reduced glycolysis, and increased reactive oxygen species production, leading to mitochondrial membrane depolarization, activation of apoptosis, and suppression of cell proliferation