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Leukodystrophies due to astroyctic dysfunction

Table 2: Summary of in vivo studies with fertility endpoints for chemical inhibitors or gene knockout experiments as evidence to support the essentiality of KEs

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Results: In livers of humans and mice with MASH, AGXT was suppressed due to promoter hypermethylation, and LDHA activity was enhanced, leading to a marked increase in hepatic oxalate in association with disease severity