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10.1016/j.tibs.2014.02.002 Trends Biochem

In general, the clinical manifestations of KGDHC deficiency relate to the severity of the deficiency

The first CIPs were discovered serendipitously by studying the mechanisms of action of natural product immunosuppressants 3,4

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Figure 2 Based on the previous refractory response, oral tacrolimus was restarted at 1 mg twice daily, using the same total duration and tapering schedule as the first course (total course, 17 days)