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Excitotoxicity Excitotoxicity, caused by abnormally high levels of amino acids such as glutamate within the synapse, plays a pivotal role in NDDs [38]

These forcesvan der Waals, hydrophobic interactions, stacking, and hydrogen bondingare precisely the same forces that govern their adhesion to biological surfaces.46 The strong affinity for binding an organic pollutant is mechanistically analogous to the strong, and often disruptive, adhesion to the phospholipid and protein components of a cell membrane, which can lead to physical stress, lipid extraction, or protein denaturation.173,174 This direct mechanistic coupling presents a profound challenge

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"A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis"