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Binding analyses were performed at 25 C using four different analyte concentrations: 1.25 M, 2.5 M, 5 M and 10 M (or 2.5 M, 5 M, 10 M and 20 M)

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Sleep deprivation induces upregulation of the main Cl-accumulating transporter, NKCC1/SLC12A2, resulting in increased neuronal Cl accumulationa reversible process modified by the NKCC1 inhibitor bumetanide 107