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Underscoring the significance of this GAPDH/Siah cell death cascade is the demonstration that the anti-Parkinsons disease drug deprenyl, which reduces neuronal cell death in both in vitro and in vivo models, prevents S-nitrosylation of GAPDH, blocks the GAPDHSiah interaction, and inhibits GAPDH nuclear translocation (90)

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Potential for Combining Antioxidants with Emerging Therapies : Antioxidants may enhance the efficacy of several treatment modalities, including immunotherapy, photodynamic therapy, gene therapy, and synergistic combinations

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The standard deviation threshold for this analysis was 50%, eliminating 6,643 transcripts out of 13,285