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Extending its immune-regulatory and nuclear roles, SHMT2 can directly interact with cytoplasmic p53, inhibiting its binding with the E3 ubiquitin ligase HDM2 and thereby preventing p53 ubiquitination and subsequent degradation (Fig

Owing to the varying duration and progression of BOO lesions, many patients still develop progressive bladder dysfunction and renal impairment after surgery, which are difficult to treat (Wang et al., 2023)

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It has been suggested that relatively high levels of progesterone, which can promote smooth muscle relaxation, may be responsible for this effect (Sweeting 1992