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Chronic psychological stress is a risk factor for dementia and AD by inducing microglial proinflammatory status (Piirainen et al., 2017)

Senolytic therapies, which target and eliminate senescent cells, may need to be administered intermittently, while senomorphics, which modulate the SASP, may be more suitable for continuous or long-term treatment.36 Additionally, in combination therapies, determining the timing and synergy of different agents is complex.258 The effects of senolytic and senomorphic agents may be enhanced or diminished depending on when and how they are administered.35 Therefore, clinical trials will need to explore various combinations and schedules to identify the most effective regimen for targeting senescence and promoting healthy aging without causing harm

Key finding: AOD 9604 increased type I collagen synthesis 2.1-fold and decreased MMP-1 expression by 64% in human fibroblasts

Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in vegans or vegetarians without malabsorption issues Patient preference where absorption is intact Maintenance therapy in some cases following initial injection therapy Typical oral doses range from 502000 micrograms daily

Capsaicin regulates fatty acid and glucose metabolism, and its intake promotes thermogenic fat oxidation and aids in weight management