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Description

Multidomain integration in the structure of the HNF-4alpha nuclear receptor complex

The rate-limiting enzyme of glutathione synthesis, -glutamylcysteine synthetase (GCS), is composed of a catalytic (GCS-HS) and regulatory subunit (GCS-LS)

Clarke CN, Lee MS, Wei W, Manyam G, Jiang ZQ, Lu Y, Morris J, Broom B, Menter D, Vilar-Sanchez E, Raghav K, Eng C, Chang GJ, Simon I, Bernards R, Overman M, Mills GB, Maru D, Kopetz S