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Roles of heat-shock proteins in innate and adaptive immunity

Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17

At the epigenetic level, MenSCs restore the expression of TET1/2 and 5-hmC levels in hepatocellular carcinoma cells in a time-dependent manner

We propose that targeting ferritin, due to its crucial role in maintaining iron homeostasis within cancer cells, represents a viable target in this context