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Hepatic histopathology also revealed lobular disorganization, inflammatory infiltration, and disrupted bile secretion (Cardoso et al., 1996

Surface morphology and elemental composition were studied with a FESEM coupled with EDX [JTM-800, JEOL, JAPAN]

The SIF was a commercially available product formulated according to pharmacopeial guidelines, consisting primarily of potassium dihydrogen phosphate (KHPO), sodium hydroxide for pH adjustment, and purified water, without digestive enzymes

These metabolites stably bound to and activated the aryl hydrocarbon receptor, triggering downstream signaling that enhanced the expression of the tight junction protein ZO-1, thereby restoring intestinal barrier integrity

Moreover, overexpression of GPX4 with adeno-associated virus significantly attenuated neuronal cell death and improved mice behavior (Zhang et al., 2018)