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To reduce the risk of withdrawal reactions, use a gradual taper to discontinue alprazolam orally disintegrating tablets or reduce the dosage [see Dosage and Administration (2.3) and Warnings and Precautions (5.3)]

In SURPASS-2, a head-to-head diabetes trial, Tirzepatide 15 mg outperformed Semaglutide 1 mg, producing 11.2 kg weight loss versus 5.7 kg (Frias et al., NEJM 2021