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Because they can potentially suppress the immune systems response to infection, they should never be used for arthritis that is triggered by an infection, called infectious arthritis

Hum Reprod 2009;24:254-269

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However, COC use is also associated with impaired fasting glucose, insulin resistance, and an elevated risk of thromboembolic events (85)

Peeking inside the Black Box: NMR Metabolomics for Optimizing Cell-Free Protein Synthesis