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The researchers noted that serious problems resulting in hospitalization were more common among elderly patients taking this combination

Reports from pharmacologically induced PD models using the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) demonstrate that specific mitochondrial toxins inhibit complex I (CI) activity, thereby promoting degeneration of dopaminergic neurons within the substantia nigra 29