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NA: Conceptualization, Funding acquisition, Investigation, Resources, Software, Validation, Visualization, Writing original draft, Writing review & editing

Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice

FGF21 is known for its effects on regulating glucose and lipid metabolism, increasing insulin sensitivity, and promoting energy expenditure

The enrichment of differentially expressed genes in the mTOR pathway in connection with sterol regulatory elements binding proteins ( Figures 3A, C ) is also interesting and in line with recent reports showing that the mTOR-driven metabolic reprogramming of macrophages increased flux through the mevalonate pathway and this process is involved in trained immunity (57)

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