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In summary, metformin induces UCP2 overexpression in adipocytes, potentially minimizing oxidative stress due to drug-induced respiratory inhibition (Table 1)

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Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

Significant differences in the studied groups of sheep suggest that the composition of the microbiome is influenced by sex hormones, i.e., estrogens (estrone, estriol, estradiol) [21,22,23,24]

However, despite these observations, the unambiguous identification of single nucleotide (SNP) risk factors for the disorder has proven remarkably difficult