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Hydrodynamic particle size distribution and colloidal stability The physicochemical characterization of MNPs and PEI-MNPs indicating the size, shape and charge was carried out to determine the potential of this system to enter the cell and nucleus

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The brain is particularly vulnerable to oxidative stress do to its high glucose-based metabolic rate, low levels of antioxidants, high levels of polyunsaturated fatty acids, and high enzymatic activities related to transition metals that catalyze the formation of free radicals (Halliwell et al., 2 O 2 in culture cells leading to neurotoxicity, and the presence of some antioxidant enzymes prevents the toxicity of the peptide (Butterfield et al., 3+ , which is at high concentrations in NFTs and A-aggregates, catalyzes the formation of reactive species such as H 2 O 2 , as well as advanced glycation end products (AGE) that are related to neurodegeneration (Smith et al., 1997b)

Hydrogen peroxide predominates as the primary ROS mediating intracellular signaling, functioning as a second messenger

In situ reduction by NaBH 4 (3 mM) converted 32 to stable conjugate 33