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Inhibition of HDAC by -OHB was correlated with global changes in transcription, including that of the genes encoding oxidative stress resistance factors Forkhead box O3a (FOXO3a) and MT2

doi: 10.1182/blood-2004-07-2520 54 StefanskiALTomiakCPleyerUDietrichTBurmesterGRDrnerT

doi: 10.1016/j.taap.2006.12.025 41

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VPA compounds interact with the active site residue ARG513, which is crucial for drug efficacy and also plays a crucial role in ligand binding and catalysis (Fig