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It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] (13), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma

797 Histochrome is a water-soluble form of echinochrome with strong antioxidant and iron-chelating effects

doi: 10.1371/journal.pone.0069362 160 ChengBZhangJShenQSunZLuoYHuY

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Figure 7 Indeed, our intracellular GSH detection assay revealed that both treatment with DMF and melatonin induced increases in ILC2 GSH levels ( Figure 7B )