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J.DsouzaC.ChenG.et al (2010a)

The copper ion (Cu2+) is an essential cofactor of lysyl oxidase, the enzyme that catalyzes the cross-linking of collagen and elastin, ensuring the three-dimensional structure and mechanical resistance of the extracellular matrix

Nevertheless, standardization of extracts with respect to key active markers such as 4-hydroxyisoleucine and trigonelline remains a necessary step for optimizing clinical efficacy and ensuring reproducibility across future therapeutic applications (149)