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When neurological symptoms are present, more intensive treatment is required: 1 mg hydroxocobalamin on alternate days until no further improvement occurs, followed by maintenance therapy every two months

Acknowledgements The authors thank Ralf Bartenschlager (University of Heidelberg, Germany) for the DENV-2 construct and Huh7 cells, Charles M Rice (Rockefeller University, NY) for the YFV-17D construct, Melanie Ott, Sakshi Tomar (Gladstone Institutes, CA) and Gregory Ebel (Colorado State University) for the ZIKV PRVABC59 construct, Beate M

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Three of these patients who resumed normal activities shortly thereafter sustained a second concussion, which resulted in more prolonged deficits in NAA/Cr ratios with delayed recovery at 45 days (Vagnozzi et al., 2008)

IM, IV, dripping 1 set per week for first 2 months