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British Medical Journal (1996)

Transferred intratumoral OT-1 GPX4 cKO CD8 + T cells displayed a similar exhausted-like phenotype (expressing PD-1 and Lag-3) (Supplemental Figure 1M) but an increased stem-like phenotype (expressing Ly108 and CD69) (Supplemental Figure 1N) compared with control CD8 + T cells

glutathione helps manage this by protecting cells from damage

They concluded that IF plays an anti-apoptotic role in response to ionizing radiation by decreasing hydroxyl radical formation, Bax-mitochondrial pathway, and JNK/p38 MAPK activation [36]