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This was an unanticipated finding since TMAO is associated with cardiovascular and metabolic disease and AD and prior human studies showed modulation of plasma TMAO by the E4 allele (Fennema et al., 2016

ALS clinical trials have also incorporated advanced electrophysiologic studies as exploratory outcomes measures for quantifying lower and upper motor neuron function, although they are limited by generalizability and interrater reliability [63, 64]

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