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Researchers are particularly interested in KPV because of its potential role in regulating inflammatory pathways

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Early administration of lactate in rat organotypic hippocampal slices after oxygen-glucose deprivation protected against neuronal death, decreased lesion size and showed better neurologic outcomes in a mouse model of middle cerebral artery occlusion (Berthet et al., 2011), in mouse cortical neuron cultures (Jourdain et al., 2016) and in rat cortex in vivo (Ros et al., 2001)

Thus, iRGD increases the tissue penetration of drugs regardless of whether it is conjugated to or coadministered with the drug 16,17,18