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But no drug is found to be effective under in vivo conditions with a smaller number of side effects

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537 PD-1 overexpression in B cells induces T cell dysfunction through an IL-10-dependent pathway, promoting tumor progression

Sulofenur [( N -(5-indanesulfonyl)- N -(4-chlorophenyl)urea, LY18664], the prototypic member of this class ( Figure 2C ), was evaluated in clinical trials on a variety of patients with kidney (Mahjoubi et al., 1993), ovary (OBrien et al., 1992), breast (Talbot et al., 1993), lung (Munshi et al., 1993), and stomach (Kamthan et al., 1992) cancers

Ricciardi et al., 2014)