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It plays a protective anti-inflammatory function across the body, including the heart (Liu et al., 2016) and immune system (Yu et al., 2015)

Shorey et al., 2013, observed increased morbidity and no reduction in lung tumorigenesis in offspring born to mothers receiving transplacental and lactational exposure to the carcinogen dibenzo[def,p]chrysene and supplemented with dietary sulforaphane (400 ppm) in contrast to many reports of chemoprotection in adult animal models [124]

As a specific substrate of GPX4, RSL3 can bind to GPX4 and inactivate it, induce the accumulation of lipid ROS and lead to ferroptosis

Scutellarein modulates the GPX4 antioxidant system to thwart ferroptosis in chronic obstructive pulmonary disease induced by LPS and cigarette smoke in mice (Liu L