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Cest le transporteur le plus important, car il est responsable du transport actif de la vitamine, et transporte environ 20 % de la B12 circulante (les 80 % restants sont lis lhaptocorrine, mais restent inactifs)

Although xCT expression is confined to the plasma membrane in normal tissues (36,39), it is upregulated in certain types of cancer, such as colorectal cancer, malignant glioma and non-small cell lung cancer, which increases cystine uptake (4042)