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npj Parkinsons Disease 9(1):141 Srivastava S, Karambhe AD, Raut US, Patel A, Narain P, Abedeen MZ et al (2025) Psychological and pharmacological strategies to address sleep disturbances in chronic illness: a review

measure ammonia level if unexplained lethargy and vomiting or changes in mental status, and also with concomitant topiramate use

Specifically, lactate triggers mitochondrial fission 1 (Fis1) lactylation at lysine 20, which promotes excessive mitochondrial fission, leading to ATP depletion, mtROS overproduction, and mitochondrial apoptosis, exacerbating S-AKI

Cartilage and osteoarthritis models: Studies in rats with induced osteoarthritis show BPC-157 reducing cartilage degradation and protecting against disease progression