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Therefore, melatonin and several melatonin analogues (e.g., ramelteon, agomelatine, and tasimelteon) are currently used to treat sleep disorders, prevent desynchronosis (jet lag), as an antioxidant, and in other conditions [76]

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Dietary genistein supplementation in laying broiler breeder hens alters the development and metabolism of offspring embryos as revealed by hepatic transcriptome analysis

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This is also an illustration of the fact that, in addition to the occurrence of merely metabolic control factors, such as the lack of adequate levels of cofactors or precursors for biosynthesis, transport limitations can occur during biotransformations (see previous section)