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However, the use of this medication requires a prolonged initial treatment period of dose-escalation to attenuate the adverse gastrointestinal effects (nausea, vomiting, diarrhea) typically associated with GLP-1R agonists, which still occurred frequently but rarely resulted in discontinuation of treatment

Figure 2 depicts the plasma concentration-time profile and the semilogarithmic plasma concentration-time curves of total dabigatran after a single oral dose of 150 mg of dabigatran etexilate capsule, under fasting conditions (A) and postprandial conditions (B)