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Fluorescence energy transfer took place when copper ions were present on the surface of the cyclam-functionalized CDs, resulting in fluorescence quenching

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HIF-1 is a master regulator of cellular adaptation to hypoxia, which translocates to the nuclei of brain capillary ECs cultured under hypoxic conditions and has been suggested as a potent therapeutic target in cerebral ischemia

Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks

Aged mice (12 months, roughly equivalent to middle age in humans) administered MOTS-c for four weeks showed improved physical performance, grip strength, and metabolic markers compared to controls