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Description

The reduction in red blood cell production is why patients with B12 deficiency report feeling so extremely fatigued (even under the slightest of efforts), sort of like the fatigue you get from altitude sickness

Efficacy-wise, AOD-9604 produces modest results (2-3 kg over 12 weeks in trials) compared to GLP-1 agonists dramatic weight loss

Implications for Health and Lifespan Improving healthspan is directly associated with a decrease in cellular senescence, which presents the prospect of increasing life expectancy rather than merely life expectancy

Nuclear NAD + is generated by nuclear NMNAT1 and is largely utilized by PARPs for DNA damage response and nuclear sirtuins such as SIRT1, SIRT6 or SIRT7 for epigenetic deacetylation 82,86