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Among the host of chelating agents used clinically, it has been shown that MchDMSA and MmDMSA are more effective chelators compared to DMSA and they demonstrate better recovery of humoral biochemical values and depleted tissue lead levels compared to DMSA

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427 Mutation of the AFT sequence results in the trafficking of F508del CFTR and ensures that CFTR functions at the cell surface, although the majority of F508del CFTR retention and degradation cannot be attributed solely to AFT sequences