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4.3.1 Melatonin inhibiting glycolysis in T-cell malignancy Glycolysis is a metabolic mechanism that transforms glucose into pyruvate and generates ATP, the primary source of energy for cells

In contrast to neurons with higher energy demands, astrocytes exhibit a greater capacity for glucose uptake, which exceeds their immediate energy requirements, as their glycolytic rate is several-fold higher than that of neurons (Barros et al., 2009)

Calcium and vitamin D may help combat glucocorticoid-induced bone loss (Homik 2000)

The mechanism may be related to the decreased inflow of iron, TF and TFR1, the upregulation of GPX4, xCT, and FTH1, and the downregulation of ACSL4, MDA and LPO levels

In addition, the activities of key enzymes that are involved in MG metabolism, including GlO1, GlO2, and D-lactate dehydrogenase, were significantly reduced in the kidney injury model, indicating a decreased MG detoxification capacity