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Future research should continue to elucidate the mechanisms by which these formulations enhance curcumins bioavailability, determine optimal dosing regimens, evaluate long-term safety, and validate clinical efficacy in well-controlled, large-scale trials [272,273]

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Organizing these schedules while maintaining accurate dosing for each component requires systematic planning

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Table 2 The antibacterial action of melatonin in vivo infected with different bacteria