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After 8 weeks, the nude mice were sacrificed, and the subcutaneous tumors were isolated and weighed, the volume was calculated by 1/2 length width 2

In the enzymatic reaction system containing magnesium ions, GTP, and excess Gln, the reaction produced ADP, glutamate (Glu), and CTP

It is seen in this figure that mDia1 activates MAPKs including ERK1/2, p38 and c-JNK leading to the activation of their respective substrate, transcription factors which eventually enters the nucleus and transcribes downstream genes responsible for cell proliferation and apoptosis

20 Briefly, for all AI xenograft studies, NOD/SCID or NSG male mice (810 weeks old) were castrated on day 0

3 and Extended Data Fig