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Antiangiogenic strategies in epithelial ovarian cancer: mechanism, resistance, and combination therapy

Repair problems in podocytes: wnt, Notch, and glomerulosclerosis

The CaP-lipid NPs can effectively deliver SOD1-targeting ASOs into the NSC-34 cell line and suppress SOD1 expression in HEK293 cells [166]

Nevertheless, multiple clinical trials testing different cyclic dinucleotides [e.g., BMS-986301 (NCT03956680) or BI 1387446 (NCT04147234)] either alone or in combination with other cancer therapies are currently ongoing and will ultimately determine the future relevance of STING agonists in a clinical setting (www.clinicaltrials.gov)

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