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High levels of mtROS may hinder effective antigen presentation at stages subsequent to antigen uptake by directly causing oxidative damage to key proteins involved in pathways such as antigen processing, transport, or loading onto MHC molecules [161]

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And not everyone who has osteopenia will develop osteoporosis

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10.1096/fj.05-3936fje FASEB J

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"Lactobacillus Rhamnosus Induces Peripheral Hyporesponsiveness in Stimulated CD4+ T Cells via Modulation of Dendritic Cell Function." Am J Clin Nutr 80.6 (2004): 1618-25

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It should be noted that eryptotic RBCs are cleared from the circulation in an efferocytosis-dependent fashion within minutes, in contrast to senescent erythrocytes [77], which require days to be engulfed by macrophages and cleared [72]

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